Protein Modification Reagents

Chemical agents used to modify the amino acid side chains of proteins in order to alter their native charges, block or expose reactive binding sites, inactivate functional groups, and change functional groups to create targets for crosslinking and labeling.

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Medchemexpress LLC Pomalidomide-PEG2-azide | 2267306-14-7 | MFCD32198604 | 96.6% | 444.40 g/mol | C19H20N6O7 | 5 MG

Pomalidomide-PEG2-azide is a pomalidomide-based cereblon (CRBN) ligand-linker conjugate featuring a two-unit polyethylene glycol spacer and an azide functional group. It is developed as a building block for targeted protein degrader (PROTAC) research and for modular conjugation via click chemistry, offering a balance of solubility and reactivity for medicinal chemistry applications.

Provides a pomalidomide scaffold for CRBN recruitment.
Two-unit PEG linker improves solubility and linker flexibility.
Azide handle enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
Suitable for use as a PROTAC building block and linker module.
Available in small-scale quantities for medicinal chemistry and assay development.